Ki Summary

Reaction Details

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Ligand

BDBM354676

Substrate/Competitor

n/a

Meas. Tech.

HTRF assay

IC50

5.5±n/a nM

Citation

Armani, E; Amari, G; Blackaby, W; Van De Poel, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9809582 Publication Date 11/7/2017

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Synonyms:

Type:

Protein

Mol. Mass.:

83318.87

Organism:

Homo sapiens (Human)

Description:

Q07343

Residue:

736

Sequence:

MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT

BDBM354676

n/a

Name

BDBM354676

Synonyms:

Single diastereoisomers [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]-5-[[[3-oxo-2-phenyl-3-[(3R)-quinuclidin-3-yl]oxypropyl]amino]-methyl]thiophene-2-carboxylate (diastereoisomers 1 and 2) | US9809582, Example 20

Type

Small organic molecule

Emp. Form.

C37H39Cl2N3O7S

Mol. Mass.

740.692

SMILES

COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC[C@H](C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,31.32,wD:35.36,(-6.47,-8.73,;-5.13,-9.5,;-3.8,-8.73,;-2.47,-9.5,;-1.13,-8.73,;-1.13,-7.19,;-2.47,-6.42,;-3.8,-7.19,;-5.13,-6.42,;-6.47,-7.19,;.2,-6.42,;1.53,-7.19,;2.87,-6.42,;2.87,-4.88,;1.53,-4.11,;4.2,-4.11,;5.53,-4.88,;6.87,-4.11,;5.53,-6.42,;4.2,-7.19,;4.2,-8.73,;.2,-4.88,;-1.13,-4.11,;-2.47,-4.88,;-1.13,-2.57,;-2.38,-1.66,;-1.9,-.2,;-.36,-.2,;.41,1.14,;-.36,2.47,;.41,3.81,;-.36,5.14,;.73,6.23,;.33,7.72,;2.21,5.83,;3.3,6.92,;4.79,6.52,;5.88,7.61,;5.48,9.1,;3.99,9.5,;2.9,8.41,;4.39,8.8,;4.39,7.21,;-1.85,5.54,;-2.25,7.03,;-3.74,7.42,;-4.83,6.34,;-4.43,4.85,;-2.94,4.45,;.11,-1.66,)|

Structure