Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM354677 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | HTRF assay | ||
IC50 | 5.5±n/a nM | ||
Citation | Armani, E; Amari, G; Blackaby, W; Van De Poel, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9809582 Publication Date 11/7/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM354677 | |||
n/a | |||
Name | BDBM354677 | ||
Synonyms: | US9809582, Example 21 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H39Cl2N3O7S | ||
Mol. Mass. | 740.692 | ||
SMILES | COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC[C@@H](C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:31.32,35.36,(-6.47,-8.73,;-5.13,-9.5,;-3.8,-8.73,;-2.47,-9.5,;-1.13,-8.73,;-1.13,-7.19,;-2.47,-6.42,;-3.8,-7.19,;-5.13,-6.42,;-6.47,-7.19,;.2,-6.42,;1.53,-7.19,;2.87,-6.42,;2.87,-4.88,;1.53,-4.11,;4.2,-4.11,;5.53,-4.88,;6.87,-4.11,;5.53,-6.42,;4.2,-7.19,;4.2,-8.73,;.2,-4.88,;-1.13,-4.11,;-2.47,-4.88,;-1.13,-2.57,;-2.38,-1.66,;-1.9,-.2,;-.36,-.2,;.41,1.14,;-.36,2.47,;.41,3.81,;-.36,5.14,;.73,6.23,;.33,7.72,;2.21,5.83,;3.3,6.92,;4.79,6.52,;5.88,7.61,;5.48,9.1,;3.99,9.5,;2.9,8.41,;4.39,8.8,;4.39,7.21,;-1.85,5.54,;-2.25,7.03,;-3.74,7.42,;-4.83,6.34,;-4.43,4.85,;-2.94,4.45,;.11,-1.66,)| | ||
Structure |