Reaction Details |
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Target | Methionine aminopeptidase 2 |
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Ligand | BDBM17431 |
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Substrate/Competitor | BDBM17353 |
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Meas. Tech. | Enzyme Inhibition Assay |
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Ki | 0.5±n/a nM |
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Citation | Marino, JP; Fisher, PW; Hofmann, GA; Kirkpatrick, RB; Janson, CA; Johnson, RK; Ma, C; Mattern, M; Meek, TD; Ryan, MD; Schulz, C; Smith, WW; Tew, DG; Tomazek, TA; Veber, DF; Xiong, WC; Yamamoto, Y; Yamashita, K; Yang, G; Thompson, SK Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem50:3777-85 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Methionine aminopeptidase 2 |
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Name: | Methionine aminopeptidase 2 |
Synonyms: | Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67 |
Type: | Enzyme |
Mol. Mass.: | 52884.45 |
Organism: | Homo sapiens (Human) |
Description: | P50579 |
Residue: | 478 |
Sequence: | MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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BDBM17431 |
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BDBM17353 |
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Name | BDBM17431 |
Synonyms: | 1,2,4-Triazole Compound, 89 | N-(5-{[(3,4-difluorophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)pyridin-3-amine |
Type | Small organic molecule |
Emp. Form. | C14H11F2N5S |
Mol. Mass. | 319.332 |
SMILES | Fc1ccc(CSc2nnc(Nc3cccnc3)[nH]2)cc1F |
Structure |
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