Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Amine oxidase [flavin-containing] A | ||
Ligand | BDBM254549 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assays-Inhibition of LSD1 | ||
Ki | >40000±n/a nM | ||
Citation | Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US10214477 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Amine oxidase [flavin-containing] A | |||
Name: | Amine oxidase [flavin-containing] A | ||
Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) | ||
Type: | Protein | ||
Mol. Mass.: | 59689.53 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P21397 | ||
Residue: | 527 | ||
Sequence: |
| ||
BDBM254549 | |||
n/a | |||
Name | BDBM254549 | ||
Synonyms: | US10214477, Example 8 | US9469597, 8 | US9670136, 8 N1-((trans)-2-(6-(3-(trifluoromethyl)phenyl)pyridin-3-yl)cyclopropyl)cyclohexane-1,4-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C21H24F3N3 | ||
Mol. Mass. | 375.4306 | ||
SMILES | NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F |r,wU:10.12,wD:8.8,(8.17,4.84,;6.83,4.07,;6.83,2.53,;5.5,1.76,;4.17,2.53,;4.17,4.07,;5.5,4.84,;2.83,1.76,;1.5,2.53,;.73,3.87,;-.04,2.53,;-1.37,1.76,;-2.71,2.53,;-4.04,1.76,;-4.04,.22,;-2.71,-.55,;-1.37,.22,;-5.37,-.55,;-6.71,.22,;-8.04,-.55,;-8.04,-2.09,;-6.75,-2.94,;-5.37,-2.09,;-6.77,-4.48,;-6.79,-6.02,;-8.31,-4.46,;-5.23,-4.51,)| | ||
Structure |