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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Amine oxidase [flavin-containing] A | ||
| Ligand | BDBM356625 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assays-Inhibition of LSD1 | ||
| Ki | 20500±n/a nM | ||
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US10214477 Publication Date 2/26/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Amine oxidase [flavin-containing] A | |||
| Name: | Amine oxidase [flavin-containing] A | ||
| Synonyms: | AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA) | ||
| Type: | Protein | ||
| Mol. Mass.: | 59689.53 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21397 | ||
| Residue: | 527 | ||
| Sequence: |
| ||
| BDBM356625 | |||
| n/a | |||
| Name | BDBM356625 | ||
| Synonyms: | US10214477, Example 11 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25F3N2O2 | ||
| Mol. Mass. | 406.4413 | ||
| SMILES | OC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(OCc2cccc(c2)C(F)(F)F)nc1 |r,wU:10.12,wD:8.8,(9.54,5.39,;8.21,4.62,;8.21,3.08,;6.87,2.31,;5.54,3.08,;5.54,4.62,;6.87,5.39,;4.21,2.31,;2.87,3.08,;2.1,4.41,;1.33,3.08,;,2.31,;-1.33,3.08,;-2.67,2.31,;-2.67,.77,;-4,,;-5.33,.77,;-6.67,,;-8,.77,;-9.34,,;-9.34,-1.54,;-8,-2.37,;-6.67,-1.54,;-8,-3.91,;-8,-5.45,;-9.54,-3.91,;-6.46,-3.91,;-1.33,,;,.77,)| | ||
| Structure | 
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