Reaction Details | |||
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Target | Lysine-specific histone demethylase 1A | ||
Ligand | BDBM254581 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assays-Inhibition of LSD1 | ||
IC50 | 34.0±n/a nM | ||
Citation | Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US10214477 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysine-specific histone demethylase 1A | |||
Name: | Lysine-specific histone demethylase 1A | ||
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 92901.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60341 | ||
Residue: | 852 | ||
Sequence: |
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BDBM254581 | |||
n/a | |||
Name | BDBM254581 | ||
Synonyms: | US10214477, Example 40 | US9469597, 40 | US9670136, 40 N1-((trans)-2-(4-cyclopropylphenyl)cyclopropyl)cyclohexane-1,4-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C18H26N2 | ||
Mol. Mass. | 270.4124 | ||
SMILES | NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)C1CC1 |r,wU:10.12,wD:8.8,(7.54,3.36,;6.21,2.59,;6.21,1.05,;4.87,.28,;3.54,1.05,;3.54,2.59,;4.87,3.36,;2.21,.28,;.87,1.05,;.1,2.39,;-.67,1.05,;-2,.28,;-3.33,1.05,;-4.67,.28,;-4.67,-1.26,;-3.33,-2.03,;-2,-1.26,;-6,-2.03,;-7.54,-2.03,;-6.77,-3.36,)| | ||
Structure |