| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, NMDA 1 |
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| Ligand | BDBM356620 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Protective Effects of Compounds on Primary Cerebellum Granule Cells of Rats |
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| EC50 | 25200±n/a nM |
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| Citation |  Wang, Y; Liu, Z; Yu, P; Sun, Y; Zhang, Z; Zhang, G; Shan, L; Yi, P; Larrick, J Amantadine nitrate compounds with neural protective effect, and preparation and medical use thereof US Patent US10214478 Publication Date 2/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, NMDA 1 |
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| Name: | Glutamate receptor ionotropic, NMDA 1 |
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| Synonyms: | Glutamate (NMDA) receptor subunit zeta 1 | Glutamate [NMDA] receptor subunit zeta-1 | Glutamate-NMDA-Channel | Glutamate-NMDA-MK801 | Glutamate-NMDA-Polyamine | Grin1 | NMDA | NMDZ1_RAT | Nmdar1 | phencyclidine |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105533.40 |
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| Organism: | RAT |
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| Description: | P35439 |
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| Residue: | 938 |
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| Sequence: | MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRL
ETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNM
TGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTC
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
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| BDBM356620 |
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| n/a |
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| Name | BDBM356620 |
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| Synonyms: | US10214478, Compound NM-002 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H20N2O3 |
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| Mol. Mass. | 240.2988 |
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| SMILES | CC12CC3CC(N)(C1)CC(CO[N+]([O-])=O)(C3)C2 |TLB:15:9:7:2.3.4,10:9:2:7.5.4,THB:8:9:2:7.5.4,8:5:2:9.15.16,15:3:7:9.8.16| |
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| Structure | 
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