| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kallikrein-1 |
|---|
| Ligand | BDBM357105 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kallikrein Assay |
|---|
| Ki | 2919±n/a nM |
|---|
| Citation |  Xu, J; Ali, A; Zhou, W; Gao, Y; Edmondson, SD; Mertz, E; Neelamkavil, SF; Liu, W; Sun, W; Shen, D; Harper, B; Zhu, C; Bara, T; Lim, Y; Yang, M Factor XIA inhibitors US Patent US10214512 Publication Date 2/26/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kallikrein-1 |
|---|
| Name: | Kallikrein-1 |
|---|
| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28874.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06870 |
|---|
| Residue: | 262 |
|---|
| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
|
|
|
|---|
| BDBM357105 |
|---|
| n/a |
|---|
| Name | BDBM357105 |
|---|
| Synonyms: | US10214512, Example 79-a | US10214512, Example 79-b | US10214512, Example 79-c | US10214512, Example 79-d |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H33ClFN7O2 |
|---|
| Mol. Mass. | 638.134 |
|---|
| SMILES | [O-][n+]1cc(ccc1C1CCCCC(Nc2ccc(F)cc2-c2cccc1c2)C(=O)N1CCCC1)-c1cc(Cl)ccc1-n1cnnn1 |
|---|
| Structure | 
|
|---|
Search and Browse
