Reaction Details |
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Target | Kallikrein-1 |
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Ligand | BDBM357118 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kallikrein Assay |
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Ki | 1.29±n/a nM |
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Citation | Xu, J; Ali, A; Zhou, W; Gao, Y; Edmondson, SD; Mertz, E; Neelamkavil, SF; Liu, W; Sun, W; Shen, D; Harper, B; Zhu, C; Bara, T; Lim, Y; Yang, M Factor XIA inhibitors US Patent US10214512 Publication Date 2/26/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Kallikrein-1 |
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Name: | Kallikrein-1 |
Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
Type: | Enzyme |
Mol. Mass.: | 28874.69 |
Organism: | Homo sapiens (Human) |
Description: | P06870 |
Residue: | 262 |
Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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BDBM357118 |
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n/a |
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Name | BDBM357118 |
Synonyms: | 5-(3-Chloro-2,6-difluorophenyl)-2-(16-fluoro-24-((methoxycarbonyl)amino)-5-methyl-4-oxo-3-aza-1(1,3),2(1,2) -dibenzenacyclononaphane-9-yl)pyridine 1-oxide | US10214512, Example 86-a |
Type | Small organic molecule |
Emp. Form. | C32H27ClF3N3O4 |
Mol. Mass. | 610.023 |
SMILES | COC(=O)Nc1ccc-2c(NC(=O)[C@H](C)CCC[C@@H](c3ccc(F)c-2c3)c2ccc(c[n+]2[O-])-c2c(F)ccc(Cl)c2F)c1 |r| |
Structure |
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