| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM357154 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kallikrein Assay |
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| Ki | 1.87±n/a nM |
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| Citation |  Xu, J; Ali, A; Zhou, W; Gao, Y; Edmondson, SD; Mertz, E; Neelamkavil, SF; Liu, W; Sun, W; Shen, D; Harper, B; Zhu, C; Bara, T; Lim, Y; Yang, M Factor XIA inhibitors US Patent US10214512 Publication Date 2/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM357154 |
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| n/a |
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| Name | BDBM357154 |
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| Synonyms: | (Z)-2-(15-cyclopropyl-24-((methoxycarbonyl)amino)-4-oxo-11H-3-aza -1(4,2)-imidazola-2(1,2)-benzenacyclononaphane-9-yl)-5-(2-(difluoromethoxy)-6-fluorophenyl)pyridine 1-oxide | US10214512, Example 113-a |
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| Type | Small organic molecule |
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| Emp. Form. | C32H30F3N5O5 |
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| Mol. Mass. | 621.6063 |
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| SMILES | COC(=O)Nc1ccc2-c3nc([nH]c3C3CC3)C(CCCCC(=O)Nc2c1)c1ccc(c[n+]1[O-])-c1c(F)cccc1OC(F)F |
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| Structure | 
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