Reaction Details |
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Target | Methionine aminopeptidase 1 |
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Ligand | BDBM17852 |
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Substrate/Competitor | BDBM17848 |
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Meas. Tech. | MetAP Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | >500000±n/a nM |
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Citation | Hu, X; Addlagatta, A; Lu, J; Matthews, BW; Liu, JO Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A103:18148-53 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Methionine aminopeptidase 1 |
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Name: | Methionine aminopeptidase 1 |
Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
Type: | Enzyme |
Mol. Mass.: | 43220.79 |
Organism: | Homo sapiens (Human) |
Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
Residue: | 386 |
Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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BDBM17852 |
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BDBM17848 |
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Name | BDBM17852 |
Synonyms: | 3-octanamido-N-(1,3-thiazol-2-yl)pyridine-2-carboxamide | pyridine-2-carboxylic acid inhibitor, 5 |
Type | Small organic molecule |
Emp. Form. | C17H22N4O2S |
Mol. Mass. | 346.447 |
SMILES | CCCCCCCC(=O)Nc1cccnc1C(=O)Nc1nccs1 |
Structure |
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