Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMethionine aminopeptidase
LigandBDBM17865
Substrate/CompetitorMet-Gly-Met-Met
Meas. Tech.EcMAP Enzyme Inhibition Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 12000±n/a nM
Citation Evdokimov, AG; Pokross, M; Walter, RL; Mekel, M; Barnett, BL; Amburgey, J; Seibel, WL; Soper, SJ; Djung, JF; Fairweather, N; Diven, C; Rastogi, V; Grinius, L; Klanke, C; Siehnel, R; Twinem, T; Andrews, R; Curnow, A Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins66:538-46 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Methionine aminopeptidase
Name:Methionine aminopeptidase
Synonyms:EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:Enzyme
Mol. Mass.:29326.96
Organism:Escherichia coli (strain K12)
Description:Full-length untagged EcMAP was expressed in E. coli.
Residue:264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACL
GYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTI
MGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEE
PQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVV
TDNGCEILTLRKDDTIPAIISHDE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM17865
Met-Gly-Met-Met
Name:Met-Gly-Met-Met
Synonyms:n/a
Type:Peptide
Mol. Mass.:468.65
Organism:n/a
Description:n/a
Residue:4
Sequence:
MGMM