Reaction Details | |||
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Target | Major prion protein | ||
Ligand | BDBM357270 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Human Platelet Aggregation Inhibition Test | ||
IC50 | 28.0±n/a nM | ||
Citation | Tran, T; Ibarra, JB; Shin, Y; Ullman, B; Zou, N; Zeng, X Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent US10214518 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Major prion protein | |||
Name: | Major prion protein | ||
Synonyms: | ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein | ||
Type: | PROTEIN | ||
Mol. Mass.: | 27671.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_158887 | ||
Residue: | 253 | ||
Sequence: |
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BDBM357270 | |||
n/a | |||
Name | BDBM357270 | ||
Synonyms: | 2-(((1s,4s)-4-((5- (methylthio)-4-(5- methylthiophen-2-yl)-3- phenyl-1H-pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid | US10214518, Compound 111 | US11098034, Compound 111 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H30N2O3S2 | ||
Mol. Mass. | 470.647 | ||
SMILES | CSc1c(-c2ccc(C)s2)c(nn1C[C@@H]1CC[C@H](COCC(O)=O)CC1)-c1ccccc1 |r,wU:14.15,17.19,(-3.06,4.75,;-4.15,3.66,;-3.75,2.18,;-4.83,1.08,;-6.32,1.48,;-7.41,.39,;-8.78,1.09,;-8.54,2.61,;-9.63,3.7,;-7.02,2.85,;-4.12,-.29,;-2.6,-.04,;-2.37,1.49,;-1.04,2.26,;.29,1.49,;.29,-.05,;1.63,-.82,;2.96,-.05,;4.29,-.82,;5.63,-.05,;6.96,-.82,;8.29,-.05,;9.63,-.82,;8.29,1.49,;2.96,1.49,;1.63,2.26,;-4.52,-1.78,;-6.01,-2.18,;-6.41,-3.66,;-5.32,-4.75,;-3.83,-4.35,;-3.43,-2.87,)| | ||
Structure |