| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Ligand | BDBM18223 |
|---|
| Substrate/Competitor | BDBM18044 |
|---|
| Meas. Tech. | Determination of IC50 |
|---|
| IC50 | 34±n/a nM |
|---|
| Citation |  Chan, DC; Fu, H; Forsch, RA; Queener, SF; Rosowsky, A Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain. J Med Chem48:4420-31 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
|---|
| Synonyms: | DHFR-TS | DRTS_TOXGO | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; T. gondii vs rat |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68757.49 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | Q07422 |
|---|
| Residue: | 610 |
|---|
| Sequence: | MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKT
GDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEG
QQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPC
DVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNG
VPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE
DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYS
LDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHR
EVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAA
LDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKP
KEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP
HGRIQMEMAV
|
|
|
|---|
| BDBM18223 |
|---|
| BDBM18044 |
|---|
| Name | BDBM18223 |
|---|
| Synonyms: | 6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimethoxyphenyl}hex-5-ynoic acid | Diaminopyrimidine analogue, 3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22N4O4 |
|---|
| Mol. Mass. | 370.4024 |
|---|
| SMILES | COc1cc(cc(Cc2cnc(N)nc2N)c1OC)C#CCCCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
