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TargetDihydrofolate reductase
LigandBDBM18761
Substrate/CompetitorBDBM18044
Meas. Tech.Thymidylate Synthase (TS) Assay
Ki 109000±n/a nM
Citation Costi MPGelain ABarlocco DGhelli SSoragni FReniero FRossi TRuberto AGuillou CCavazzuti ACasolari CFerrari S Antibacterial agent discovery using thymidylate synthase biolibrary screening. J Med Chem 49:5958-68 (2006) [PubMed]  Article
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM18761
BDBM18044
NameBDBM18761
Synonyms:1,2-naphthalein derivative, 8 | 5,5-bis(3-fluoro-4-hydroxyphenyl)-4-oxatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),7,10,12-pentaen-3-one
TypeSmall organic molecule
Emp. Form.C24H14F2O4
Mol. Mass.404.3624
SMILESOc1ccc(cc1F)C1(OC(=O)c2c1ccc1ccccc21)c1ccc(O)c(F)c1
Structure
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