| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fatty-acid amide hydrolase 1 [30-579] |
|---|
| Ligand | BDBM359728 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radiometric Assay |
|---|
| IC50 | 0.230±n/a nM |
|---|
| Citation |  Piomelli, D; Bandiera, T; Scarpelli, R Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments US Patent US9822068 Publication Date 11/21/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fatty-acid amide hydrolase 1 [30-579] |
|---|
| Name: | Fatty-acid amide hydrolase 1 [30-579] |
|---|
| Synonyms: | Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1 |
|---|
| Type: | Single-pass membrane protein; homodimer |
|---|
| Mol. Mass.: | 60474.00 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P97612 (aa 30-579) |
|---|
| Residue: | 550 |
|---|
| Sequence: | RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSG
ELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKG
HDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWK
SSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGC
VYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGY
YETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFL
QNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQH
EIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPV
TTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVE
QLMTPQKQPS
|
|
|
|---|
| BDBM359728 |
|---|
| n/a |
|---|
| Name | BDBM359728 |
|---|
| Synonyms: | US10435355, Example 12 | US9822068, 12 | [3-(3-carbamoylphenyl)-5- fluoro-phenyl]N- cyclohexylcarbamate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21FN2O3 |
|---|
| Mol. Mass. | 356.3907 |
|---|
| SMILES | NC(=O)c1cccc(c1)-c1cc(F)cc(OC(=O)NC2CCCCC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
