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TargetThyroid hormone receptor beta [209-461]
LigandBDBM18828
Substrate/CompetitorPeptide SRC2-2
Meas. Tech.Fluorescence Polarization (FP) Competition Assay
IC50 23200±n/a nM
Citation Arnold, LA; Kosinski, A; Estebanez-Perpina, E; Fletterick, RJ; Guy, RK Inhibitors of the Interaction of a Thyroid Hormone Receptor and Coactivators: Preliminary Structure-Activity Relationships. J Med Chem50:5269-5280 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Thyroid hormone receptor beta [209-461]
Name:Thyroid hormone receptor beta [209-461]
Synonyms:ERBA2 | NR1A2 | THB_HUMAN | THR1 | THRB | Thyroid Hormone Receptor (TR-beta)
Type:Ligand-Binding Domain
Mol. Mass.:28584.77
Organism:Homo sapiens (Human)
Description:The hTRbeta LBD (His6 T209-D461) was cloned and expressed in E. coli.
Residue:253
Sequence:
THKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEA
FSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETL
TLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLAC
VERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPT
ELFPPLFLEVFED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM18828
Peptide SRC2-2
Name:Peptide SRC2-2
Synonyms:n/a
Type:Peptide
Mol. Mass.:2334.76
Organism:n/a
Description:The peptide is labeled with 5-iodoacetamidofluorescien.
Residue:20
Sequence:
CLKEKHKILHRLLQDSSSPV