| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM360351 |
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| Substrate/Competitor | n/a |
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| IC50 | 10.00±n/a nM |
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| Citation |  Liverton, N; Beshore, DC; Kuduk, SD; Luo, Y; Meng, N; Yu, T Oxazole orexin receptor antagonists US Patent US9828368 Publication Date 11/28/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
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| Type: | Protein |
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| Mol. Mass.: | 46817.55 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P56718 |
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| Residue: | 416 |
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| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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| BDBM360351 |
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| n/a |
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| Name | BDBM360351 |
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| Synonyms: | US9828368, Example 13 | US9828368, Example 14 | US9828368, Example 15 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20BrN5O4 |
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| Mol. Mass. | 474.308 |
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| SMILES | COC(=O)c1nc(oc1Br)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1 |r| |
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| Structure | 
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