| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP [124-240] |
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| Ligand | BDBM243099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay for BIR2 and BIR3 |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.000±n/a nM |
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| Comments | extracted |
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| Citation |  Chen, S; Donnell, AF; Kester, RF; Le, K; Lou, Y; Michoud, C; Remiszewski, S; Rupert, KC; Weisel, M Tetrahydro-benzodiazepinones US Patent US10053431 Publication Date 8/21/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase XIAP [124-240] |
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| Name: | E3 ubiquitin-protein ligase XIAP [124-240] |
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| Synonyms: | 6x Histidine-tagged BIR2 domain | API3 | BIR2 (aa 124-240) | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR2)(C202A/C213G) | IAP3 | XIAP | XIAP Bir2 | XIAP_HUMAN | amino acids 124-240 of XIAP |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 13562.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170[124-240] |
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| Residue: | 117 |
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| Sequence: | RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE
LASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE
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| BDBM243099 |
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| n/a |
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| Name | BDBM243099 |
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| Synonyms: | (S)—N—((S)-5-(4-Acetylbenzoyl)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)butanamide hydrochloride | US10053431, 79 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H35BrN4O5 |
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| Mol. Mass. | 671.58 |
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| SMILES | CCC(NC)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(C)=O)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O |r| |
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| Structure | 
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