| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP [241-356] |
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| Ligand | BDBM50441834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay for BIR2 and BIR3 |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 24770±n/a nM |
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| Comments | extracted |
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| Citation |  Chen, S; Donnell, AF; Kester, RF; Le, K; Lou, Y; Michoud, C; Remiszewski, S; Rupert, KC; Weisel, M Tetrahydro-benzodiazepinones US Patent US10053431 Publication Date 8/21/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| E3 ubiquitin-protein ligase XIAP [241-356] |
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| Name: | E3 ubiquitin-protein ligase XIAP [241-356] |
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| Synonyms: | API3 | BIR3 (aa 241-356) | BIR3 domain | BIRC4 | IAP3 | XIAP | XIAP Bir3 | XIAP_HUMAN | amino acids 241-356 of XIAP |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 14548.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170[241-356] |
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| Residue: | 125 |
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| Sequence: | MRHHHHHHRSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYA
LGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEEC
LVRTT
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| BDBM50441834 |
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| n/a |
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| Name | BDBM50441834 |
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| Synonyms: | CHEMBL2436330 | US10053431, 91a |
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| Type | Small organic molecule |
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| Emp. Form. | C32H31BrN4O4 |
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| Mol. Mass. | 615.517 |
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| SMILES | CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccccc2)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O |r| |
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| Structure | 
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