| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Procathepsin L |
|---|
| Ligand | BDBM19514 |
|---|
| Substrate/Competitor | BDBM19480 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 24±n/a nM |
|---|
| Citation |  Gauthier, JY; Black, WC; Courchesne, I; Cromlish, W; Desmarais, S; Houle, R; Lamontagne, S; Li, CS; Massé, F; McKay, DJ; Ouellet, M; Robichaud, J; Truchon, JF; Truong, VL; Wang, Q; Percival, MD The identification of potent, selective, and bioavailable cathepsin S inhibitors. Bioorg Med Chem Lett17:4929-33 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Procathepsin L |
|---|
| Name: | Procathepsin L |
|---|
| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37557.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Purchased from Calbiochem (San Diego, CA). |
|---|
| Residue: | 333 |
|---|
| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
|
|
|
|---|
| BDBM19514 |
|---|
| BDBM19480 |
|---|
| Name | BDBM19514 |
|---|
| Synonyms: | (2R)-N-(1-cyanocyclopropyl)-3-[(3,4-dichlorobenzene)sulfonyl]-2-{[(1S)-2,2,2-trifluoro-1-phenylethyl]amino}propanamide | trifluoroethylamine inhibitor, 24 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18Cl2F3N3O3S |
|---|
| Mol. Mass. | 520.352 |
|---|
| SMILES | FC(F)(F)[C@@H](N[C@@H](CS(=O)(=O)c1ccc(Cl)c(Cl)c1)C(=O)NC1(CC1)C#N)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
