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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase SYK | ||
| Ligand | BDBM243363 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro SYK Inhibition Assay | ||
| pH | 7.8±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <500±n/a nM | ||
| Comments | extracted | ||
| Citation |  Benjahad, A; Martin, J; Schalon, C; Pez, D; Chevenier, E; Sandrinelli, F; Picoul, W; Moussy, A Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors US Patent US10053455 Publication Date 8/21/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase SYK | |||
| Name: | Tyrosine-protein kinase SYK | ||
| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 72079.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P43405 | ||
| Residue: | 635 | ||
| Sequence: |
| ||
| BDBM243363 | |||
| n/a | |||
| Name | BDBM243363 | ||
| Synonyms: | 4-{5-[3-(4-Pyridin-3-yl- pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-4,7- diaza-spiro[2.5]octan-8- one | US10053455, 019 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H24N7O2 | ||
| Mol. Mass. | 454.5038 | ||
| SMILES | C[N]1=C(OC(=C1)c1cccc(Nc2nccc(n2)-c2cccnc2)c1)N1CCNC(=O)C11CC1 |c:4,t:1,(-2.45,2.81,;-1.87,2.63,;-3.35,3.03,;-4.19,1.74,;-3.22,.54,;-1.79,1.09,;-3.62,-.94,;-5.11,-1.34,;-5.51,-2.83,;-4.42,-3.92,;-2.93,-3.52,;-1.84,-4.61,;-.35,-4.21,;.04,-2.72,;1.53,-2.33,;2.62,-3.41,;2.22,-4.9,;.73,-5.3,;3.31,-5.99,;4.64,-5.22,;5.98,-5.99,;5.98,-7.53,;4.64,-8.3,;3.31,-7.53,;-2.53,-2.03,;-3.91,4.47,;-5.43,4.71,;-5.98,6.15,;-5.01,7.34,;-3.49,7.1,;-2.52,8.3,;-2.94,5.67,;-1.74,4.7,;-1.5,6.22,)| | ||
| Structure | 
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