| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM243365 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro SYK Inhibition Assay |
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| pH | 7.8±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1250±n/a nM |
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| Comments | extracted |
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| Citation |  Benjahad, A; Martin, J; Schalon, C; Pez, D; Chevenier, E; Sandrinelli, F; Picoul, W; Moussy, A Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors US Patent US10053455 Publication Date 8/21/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM243365 |
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| n/a |
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| Name | BDBM243365 |
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| Synonyms: | 4-{5-[3-(4-Methyl- pyridin-2-ylamino)- phenyl]oxazol-2-yl}-4,7- diaza-spiro[2.5]octan-8- one | US10053455, 021 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N5O2 |
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| Mol. Mass. | 375.4237 |
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| SMILES | Cc1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)c1 |
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| Structure | 
|
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