Reaction Details |
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Target | Cathepsin S |
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Ligand | BDBM19812 |
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Substrate/Competitor | BDBM19490 |
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Meas. Tech. | In Vitro Enzyme Inhibition Assay |
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Ki | 290±n/a nM |
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Citation | Marquis, RW; Ru, Y; Zeng, J; Trout, RE; LoCastro, SM; Gribble, AD; Witherington, J; Fenwick, AE; Garnier, B; Tomaszek, T; Tew, D; Hemling, ME; Quinn, CJ; Smith, WW; Zhao, B; McQueney, MS; Janson, CA; D'Alessio, K; Veber, DF Cyclic ketone inhibitors of the cysteine protease cathepsin K. J Med Chem44:725-36 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin S |
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Name: | Cathepsin S |
Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
Type: | Protein |
Mol. Mass.: | 37507.38 |
Organism: | Homo sapiens (Human) |
Description: | P25774 |
Residue: | 331 |
Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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BDBM19812 |
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BDBM19490 |
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Name | BDBM19812 |
Synonyms: | [(2S)-1-{3-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanamido]-4-oxopyrrolidin-1-yl}-4-methyl-1-oxopentan-2-yl](methyl)azanium chloride | pyrrolidinone analogue, 29 |
Type | Small organic molecule |
Emp. Form. | C25H39N4O5 |
Mol. Mass. | 475.6004 |
SMILES | C[NH2+][C@@H](CC(C)C)C(=O)N1CC(NC(=O)[C@H](CC(C)C)NC(=O)OCc2ccccc2)C(=O)C1 |r| |
Structure |
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