| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin K |
|---|
| Ligand | BDBM19851 |
|---|
| Substrate/Competitor | BDBM19480 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 0.58±n/a nM |
|---|
| Citation |  Crane, SN; Black, WC; Palmer, JT; Davis, DE; Setti, E; Robichaud, J; Paquet, J; Oballa, RM; Bayly, CI; McKay, DJ; Somoza, JR; Chauret, N; Seto, C; Scheigetz, J; Wesolowski, G; Massé, F; Desmarais, S; Ouellet, M Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J Med Chem49:1066-79 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Cathepsin K |
|---|
| Name: | Cathepsin K |
|---|
| Synonyms: | CATK_RABIT | CTSK |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36879.51 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | n/a |
|---|
| Residue: | 329 |
|---|
| Sequence: | MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
|
|
|
|---|
| BDBM19851 |
|---|
| BDBM19480 |
|---|
| Name | BDBM19851 |
|---|
| Synonyms: | (1R,2R)-5,5-dichloro-N-(cyanomethyl)-2-{2-[4-(methylsulfanyl)phenyl]phenyl}cyclohexane-1-carboxamide | Cyclohexanecarboxamide derivative, rac-34c | racemic mixture |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22Cl2N2OS |
|---|
| Mol. Mass. | 433.394 |
|---|
| SMILES | CSc1ccc(cc1)-c1ccccc1[C@@H]1CCC(Cl)(Cl)C[C@H]1C(=O)NCC#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
