Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM19850 |
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Substrate/Competitor | BDBM19480 |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 19±n/a nM |
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Citation | Crane, SN; Black, WC; Palmer, JT; Davis, DE; Setti, E; Robichaud, J; Paquet, J; Oballa, RM; Bayly, CI; McKay, DJ; Somoza, JR; Chauret, N; Seto, C; Scheigetz, J; Wesolowski, G; Massé, F; Desmarais, S; Ouellet, M Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J Med Chem49:1066-79 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_RABIT | CTSK |
Type: | Enzyme |
Mol. Mass.: | 36879.51 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | n/a |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
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BDBM19850 |
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BDBM19480 |
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Name | BDBM19850 |
Synonyms: | (1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-[2-(4-fluorophenyl)phenyl]cyclohexane-1-carboxamide | Cyclohexanecarboxamide derivative, rac-34b | racemic mixture |
Type | Small organic molecule |
Emp. Form. | C21H19F3N2O |
Mol. Mass. | 372.3836 |
SMILES | Fc1ccc(cc1)-c1ccccc1[C@@H]1CCC(F)(F)C[C@H]1C(=O)NCC#N |r| |
Structure |
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