| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor |
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| Ligand | BDBM19924 |
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| Substrate/Competitor | BDBM17289 |
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| Meas. Tech. | Competition-Based Ligand Binding Assay and Transactivation Assay. |
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| pH | 8±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 15297±n/a nM |
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| EC50 | 9344±n/a nM |
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| Citation |  Güngör, T; Chen, Y; Golla, R; Ma, Z; Corte, JR; Northrop, JP; Bin, B; Dickson, JK; Stouch, T; Zhou, R; Johnson, SE; Seethala, R; Feyen, JH Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. J Med Chem49:2440-55 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Estrogen receptor |
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| Name: | Estrogen receptor |
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| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 66230.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372 |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM19924 |
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| BDBM17289 |
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| Name | BDBM19924 |
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| Synonyms: | 3-arylquinazolinone, 1ao | 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-methyl-3,4-dihydroquinazolin-4-one |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N2O4 |
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| Mol. Mass. | 284.2668 |
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| SMILES | Cc1c(O)cc(O)c2c1ncn(-c1ccc(O)cc1)c2=O |
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| Structure | 
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