| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM246943 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | P2X7 FLIPR Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 3.70±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ameriks, MK; Rech, JC; Savall, BM; Wall, JL Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators US Patent US10053463 Publication Date 8/21/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68602.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99572 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
|
|
|
|---|
| BDBM246943 |
|---|
| n/a |
|---|
| Name | BDBM246943 |
|---|
| Synonyms: | (5S)-3-(2,3-Dichlorophenyl)-5-methyl-8-pyrazin-2-yl-5,6-dihydrobis[1,2,4]triazolo[4,3-a:3′,4′-c]pyrazine | US10053463, 100 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12Cl2N8 |
|---|
| Mol. Mass. | 399.237 |
|---|
| SMILES | C[C@H]1Cn2c(nnc2-c2cnccn2)-c2nnc(-c3cccc(Cl)c3Cl)n12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
