| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM246956 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P2X7 FLIPR Assay |
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| pH | 7.4±n/a |
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| IC50 | 2.70±n/a nM |
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| Comments | extracted |
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| Citation |  Ameriks, MK; Rech, JC; Savall, BM; Wall, JL Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators US Patent US10053463 Publication Date 8/21/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | P2RX7_MOUSE | P2rx7 | P2x7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68405.16 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1473824 |
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| Residue: | 595 |
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| Sequence: | MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISS
VHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCP
EYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPA
LLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYK
ENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSS
AFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKS
LQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCG
NCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEA
TNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
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| BDBM246956 |
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| n/a |
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| Name | BDBM246956 |
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| Synonyms: | (5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-8-(4-methoxypyridin-2-yl)-5-methyl-5,6-dihydrobis[1,2,4]triazolo[4,3-a:3′,4′-c]pyrazine | US10053463, 113 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15ClF3N7O |
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| Mol. Mass. | 461.828 |
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| SMILES | COc1ccnc(c1)-c1nnc2-c3nnc(-c4cccc(c4Cl)C(F)(F)F)n3[C@@H](C)Cn12 |r| |
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| Structure | 
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