| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM246967 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | P2X7 FLIPR Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 4.20±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ameriks, MK; Rech, JC; Savall, BM; Wall, JL Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators US Patent US10053463 Publication Date 8/21/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | P2RX7_MOUSE | P2rx7 | P2x7 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68405.16 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1473824 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISS
VHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCP
EYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPA
LLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYK
ENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSS
AFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKS
LQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCG
NCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEA
TNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
|
|
|
|---|
| BDBM246967 |
|---|
| n/a |
|---|
| Name | BDBM246967 |
|---|
| Synonyms: | (S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methyl-8-(pyridin-2-yl)-5,6-dihydrobis([1,2,4]triazolo)[4,3-a:3′,4′-c]pyrazine | US10053463, 124 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H13ClF3N7 |
|---|
| Mol. Mass. | 431.802 |
|---|
| SMILES | C[C@H]1Cn2c(nnc2-c2ccccn2)-c2nnc(-c3cccc(c3Cl)C(F)(F)F)n12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
