| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM246968 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | P2X7 FLIPR Assay |
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| pH | 7.4±n/a |
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| IC50 | 1.60±n/a nM |
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| Comments | extracted |
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| Citation |  Ameriks, MK; Rech, JC; Savall, BM; Wall, JL Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators US Patent US10053463 Publication Date 8/21/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM246968 |
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| n/a |
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| Name | BDBM246968 |
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| Synonyms: | (S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methyl-8-(4-methylpyridin-2-yl)-5,6-dihydrobis([1,2,4]triazolo)[4,3-a:3′,4′-c]pyrazine | US10053463, 125 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15ClF3N7 |
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| Mol. Mass. | 445.828 |
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| SMILES | C[C@H]1Cn2c(nnc2-c2cc(C)ccn2)-c2nnc(-c3cccc(c3Cl)C(F)(F)F)n12 |r| |
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| Structure | 
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