| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Ligand | BDBM365731 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 5.5±n/a nM |
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| Citation |  Lan, R; Chen, X; Xiao, Y; Huck, BR; Goutopoulos, A Heterocycles as modulators of kinase activity US Patent US9867826 Publication Date 1/16/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 [T412E] |
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| Name: | Ribosomal protein S6 kinase beta-1 [T412E] |
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| Synonyms: | KS6B1_HUMAN | P70S6K (T412E) | RPS6KB1 | STK14A | p70 ribosomal S6 kinase alpha (P70S6K)(T412E) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59166.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23443[T412E] |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFEYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM365731 |
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| n/a |
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| Name | BDBM365731 |
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| Synonyms: | 5-Chloro-6-{(3S,4R)-4-[1-(2-dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-3-fluoro-piperidin-1-yl}-pyrimidin-4-ylamine | US9867826, Compound 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25ClF5N7 |
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| Mol. Mass. | 529.937 |
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| SMILES | CN(C)CCn1cc(nc1[C@H]1CCN(C[C@H]1F)c1ncnc(N)c1Cl)-c1ccc(F)c(c1)C(F)(F)F |
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| Structure | 
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