Ki Summary

Reaction Details

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Target

Heat shock protein HSP 90-beta

Ligand

BDBM15374

Substrate/Competitor

BDBM10852

Meas. Tech.

Her-2 Degradation Assay

7.2±n/a

Temperature

310.15±n/a K

EC50

40000±n/a nM

Citation

Biamonte, MA; Shi, J; Hong, K; Hurst, DC; Zhang, L; Fan, J; Busch, DJ; Karjian, PL; Maldonado, AA; Sensintaffar, JL; Yang, YC; Kamal, A; Lough, RE; Lundgren, K; Burrows, FJ; Timony, GA; Boehm, MF; Kasibhatla, SR Orally active purine-based inhibitors of the heat shock protein 90. J Med Chem49:817-28 (2006) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock protein HSP 90-beta

Name:

Heat shock protein HSP 90-beta

Synonyms:

Type:

Molecular Chaperone

Mol. Mass.:

83229.45

Organism:

Homo sapiens (Human)

Description:

P08238

Residue:

724

Sequence:

MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT
DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG
ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK
VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE
DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE
YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV
FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA
EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ
KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG
LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA
NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE
TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM
EEVD

BDBM15374

BDBM10852

Name

BDBM15374

Synonyms:

9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine | 9-butyl-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine | CHEMBL113690 | PU3 | Purine-Based Inhibitor 1

Type

Small organic molecule

Emp. Form.

C19H25N5O3

Mol. Mass.

371.4335

SMILES

CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2)nc2c(N)ncnc12

Structure