| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acid ceramidase |
|---|
| Ligand | BDBM367200 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescent-based In Vitro Assa |
|---|
| IC50 | 23.0±5 nM |
|---|
| Citation |  Piomelli, D; Pagliuca, C; Pizzirani, D; Bach, A; Realini, N; De Vivo, M Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments US Patent US10226452 Publication Date 3/12/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acid ceramidase |
|---|
| Name: | Acid ceramidase |
|---|
| Synonyms: | ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 44662.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13510 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
|
|
|
|---|
| BDBM367200 |
|---|
| n/a |
|---|
| Name | BDBM367200 |
|---|
| Synonyms: | 7-methyl-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-3-carboxamide | US10226452, Example 18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20N2O3 |
|---|
| Mol. Mass. | 324.3737 |
|---|
| SMILES | Cc1cccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc12 |
|---|
| Structure | 
|
|---|
Search and Browse
