Reaction Details |
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Target | Serine/threonine-protein kinase MARK2 |
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Ligand | BDBM247045 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PAR-1 FLIPR Assay |
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IC50 | 104±n/a nM |
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Citation | Yang, Z; Zhang, F; Dong, G; Knowles, SL; Maletic, M Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists US Patent US9701669 Publication Date 7/11/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase MARK2 |
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Name: | Serine/threonine-protein kinase MARK2 |
Synonyms: | ELKL motif kinase 1 | EMK1 | MAP/microtubule affinity-regulating kinase 2 | MARK2 | MARK2_HUMAN | PAR1 homolog | Par-1 | Serine/threonine-protein kinase MARK2 |
Type: | PROTEIN |
Mol. Mass.: | 87953.09 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774586 |
Residue: | 788 |
Sequence: | MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP
NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE
SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
KIANELKL
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BDBM247045 |
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n/a |
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Name | BDBM247045 |
Synonyms: | 2-((1R,3aR,6S, 7R,7aS)-5,5- difluoro-7- ((E)-2-(2'- methoxy-[3,3'- bipyridin]-6- yl)vinyl)-1,6- dimethyl-3- oxooctahydro- isobenzofuran- 3a-yl)acetamide | US9701669, 16 |
Type | Small organic molecule |
Emp. Form. | C25H27F2N3O4 |
Mol. Mass. | 471.4964 |
SMILES | COc1ncccc1-c1ccc(\C=C\[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@]3(CC(N)=O)CC(F)(F)[C@H]2C)nc1 |r| |
Structure |
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