Reaction Details |
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Target | Orotidine 5'-phosphate decarboxylase |
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Ligand | BDBM21340 |
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Substrate/Competitor | BDBM21336 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 328.15±n/a K |
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Ki | 12400±0.7 nM |
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Citation | Bello, AM; Poduch, E; Liu, Y; Wei, L; Crandall, I; Wang, X; Dyanand, C; Kain, KC; Pai, EF; Kotra, LP Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase. J Med Chem51:439-48 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Orotidine 5'-phosphate decarboxylase |
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Name: | Orotidine 5'-phosphate decarboxylase |
Synonyms: | OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF |
Type: | Enzyme |
Mol. Mass.: | 24909.45 |
Organism: | Methanobacterium thermoautotrophicum |
Description: | n/a |
Residue: | 228 |
Sequence: | MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREV
FLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISP
GVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
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BDBM21340 |
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BDBM21336 |
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Name | BDBM21340 |
Synonyms: | 6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4R,5R)-5-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C8H12N3O9P |
Mol. Mass. | 325.1693 |
SMILES | O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc(=O)[nH]c1=O |r| |
Structure |
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