Reaction Details |
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Target | Angiotensin-converting enzyme 2 |
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Ligand | BDBM21454 |
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Substrate/Competitor | BDBM21453 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 6.8±n/a |
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Temperature | 298.15±n/a K |
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Ki | 300±n/a nM |
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Citation | Mores, A; Matziari, M; Beau, F; Cuniasse, P; Yiotakis, A; Dive, V Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. J Med Chem51:2216-2226 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Angiotensin-converting enzyme 2 |
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Name: | Angiotensin-converting enzyme 2 |
Synonyms: | ACE-related carboxypeptidase | ACE2 | ACE2_HUMAN | ACEH | Angiotensin-converting enzyme homolog | Angiotensin-converting enzyme-related carboxypeptidase | Metalloprotease MPROT15 |
Type: | Enzyme |
Mol. Mass.: | 92448.86 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 805 |
Sequence: | MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQ
NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTIL
NTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY
EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL
HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ
AWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILM
CTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS
IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM
KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLH
KCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK
NSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKN
QMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDN
SLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENP
YASIDISKGENNPGFQNTDDVQTSF
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BDBM21454 |
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BDBM21453 |
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Name | BDBM21454 |
Synonyms: | 2-[({1-[(benzyloxy)carbonyl]pyrrolidin-2-yl}(hydroxy)phosphoryl)methyl]-4-methylpentanoic acid | Phosphinic Peptide Inhibitor, 13 |
Type | Small organic molecule |
Emp. Form. | C19H28NO6P |
Mol. Mass. | 397.4025 |
SMILES | CC(C)CC(CP(O)(O)C1=CCCN1C(=O)OCc1ccccc1)C(O)=O |t:9| |
Structure |
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