| Reaction Details |
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 | Report a problem with these data |
| Target | Angiotensin-converting enzyme 2 |
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| Ligand | BDBM21466 |
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| Substrate/Competitor | BDBM21453 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 6.8±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 7±n/a nM |
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| Citation |  Mores, A; Matziari, M; Beau, F; Cuniasse, P; Yiotakis, A; Dive, V Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. J Med Chem51:2216-2226 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Angiotensin-converting enzyme 2 |
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| Name: | Angiotensin-converting enzyme 2 |
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| Synonyms: | ACE-related carboxypeptidase | ACE2 | ACE2_HUMAN | ACEH | Angiotensin-converting enzyme homolog | Angiotensin-converting enzyme-related carboxypeptidase | Metalloprotease MPROT15 |
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| Type: | Enzyme |
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| Mol. Mass.: | 92448.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 805 |
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| Sequence: | MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQ
NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTIL
NTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLY
EEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHL
HAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQ
AWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILM
CTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKS
IGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEM
KREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLH
KCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNK
NSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKN
QMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDN
SLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENP
YASIDISKGENNPGFQNTDDVQTSF
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| BDBM21466 |
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| BDBM21453 |
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| Name | BDBM21466 |
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| Synonyms: | 5-{2-[(2-benzyl-2-carboxyethyl)(hydroxy)phosphoryl]pyrrolidin-1-yl}-4-acetamido-5-oxopentanoic acid | Phosphinic Peptide Inhibitor, 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29N2O8P |
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| Mol. Mass. | 468.4373 |
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| SMILES | CC(=O)NC(CCC(O)=O)C(=O)N1CCC=C1P(O)(O)CC(Cc1ccccc1)C(O)=O |c:15| |
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| Structure | 
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