| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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| Ligand | BDBM370233 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CDK4/Cyclin D3 Mobility Shift Assay |
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| Ki | 0.340±n/a nM |
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| Citation |  Freeman-Cook, KD; Hoffman, RL; Nagata, A; Ninkovic, S CDK2/4/6 inhibitors US Patent US10233188 Publication Date 3/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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| Synonyms: | CDK4/Cyclin D3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1806445 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
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| Synonyms: | CCND3 | CCND3_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 32521.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30281 |
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| Residue: | 292 |
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| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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| BDBM370233 |
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| n/a |
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| Name | BDBM370233 |
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| Synonyms: | US10233188, Example 120 | US10800783, Example 120 | US11396512, Example 120 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N6O4S |
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| Mol. Mass. | 460.55 |
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| SMILES | C[C@@]1(O)CCC[C@H]1n1c2nc(NC3CCN(CC3)S(C)(=O)=O)ncc2cc(CC#N)c1=O |r| |
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| Structure | 
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