| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 8 |
|---|
| Ligand | BDBM21919 |
|---|
| Substrate/Competitor | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Meas. Tech. | Tpl2/Cot Kinase Assay |
|---|
| pH | 7.2±n/a |
|---|
| Temperature | 303.15±n/a K |
|---|
| IC50 | 350±n/a nM |
|---|
| Citation |  Green N; Hu Y; Janz K; Li HQ; Kaila N; Guler S; Thomason J; Joseph-McCarthy D; Tam SY; Hotchandani R; Wu J; Huang A; Wang Q; Leung L; Pelker J; Marusic S; Hsu S; Telliez JB; Hall JP; Cuozzo JW; Lin LL Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles. J Med Chem 50:4728-45 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 8 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 8 |
|---|
| Synonyms: | C-COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | Mitogen-activated protein kinase kinase kinase 8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 52916.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 467 |
|---|
| Sequence: | MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
|
|
|
|---|
| BDBM21919 |
|---|
| Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Synonyms: | GST fusion of MAP kinase kinase 1 | GST-MEK1 | glutathione S-transferase-MAP kinase kinase 1 |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 43453 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | Rabbit MEK1 was purchased from Millipore. |
|---|
| Residue: | 393 |
|---|
| Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
|
|
|
|---|
Search and Browse
