| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM22108 |
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| Substrate/Competitor | BDBM22104 |
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| Meas. Tech. | PNP Inhibition Assay |
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| pH | 7.7±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 1.8±0.3 nM |
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| Km | 40000±n/a nM |
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| Comments | Ki is the dissociation constant for the first step in the two-step binding characteristic of slow-onset tight-binding inhibition. |
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| Citation |  Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem51:948-56 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM22108 |
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| BDBM22104 |
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| Name | BDBM22108 |
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| Synonyms: | 7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one | Azetidine based compound, (+/-) 42 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14N4O2 |
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| Mol. Mass. | 234.2545 |
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| SMILES | OCC1CCN1Cc1c[nH]c2c1nc[nH]c2=O |
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| Structure | 
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