Reaction Details |
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Target | Purine nucleoside phosphorylase |
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Ligand | BDBM22103 |
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Substrate/Competitor | BDBM22104 |
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Meas. Tech. | PNP Inhibition Assay |
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pH | 7.7±n/a |
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Temperature | 295.15±n/a K |
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Ki | >10000±n/a nM |
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Km | 5000±n/a nM |
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Citation | Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem51:948-56 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Purine nucleoside phosphorylase |
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Name: | Purine nucleoside phosphorylase |
Synonyms: | Purine Nucleoside Phosphorylase (PNP) | pfPNP |
Type: | Enzyme |
Mol. Mass.: | 26857.85 |
Organism: | Plasmodium falciparum |
Description: | n/a |
Residue: | 245 |
Sequence: | MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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BDBM22103 |
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BDBM22104 |
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Name | BDBM22103 |
Synonyms: | 7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one | Azetidine based compound, 34 |
Type | Small organic molecule |
Emp. Form. | C12H16N4O3 |
Mol. Mass. | 264.2804 |
SMILES | OCC1(CO)CN(Cc2c[nH]c3c2nc[nH]c3=O)C1 |
Structure |
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