Reaction Details |
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Target | Tyrosine-protein kinase Lyn |
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Ligand | BDBM340073 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Lyn Enzyme Activity |
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EC50 | >1000±n/a nM |
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Citation | Barf, TA; Jans, CG; de Man, AP; Oubrie, AA; Raaijmakers, HC; Rewinkel, JB; Sterrenburg, JG; Wijkmans, JC 4-imidazopyridazin-1-yl-benzamides as BTK inhibitors US Patent US10239883 Publication Date 3/26/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lyn |
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Name: | Tyrosine-protein kinase Lyn |
Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
Type: | Protein |
Mol. Mass.: | 58575.92 |
Organism: | Homo sapiens (Human) |
Description: | P07948 |
Residue: | 512 |
Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
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BDBM340073 |
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n/a |
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Name | BDBM340073 |
Synonyms: | 4-(8-amino-3-((S)-1-((E)-4- methoxybut-2-enoyl)pyrrolidin-2- yl)imidazo[1,5-a]pyrazin-1-yl)-3- methyl-N-(4-propylpyridin-2- yl)benzamide | US10239883, Example 87 | US10934296, Example 87 | US9758524, Example 87 |
Type | Small organic molecule |
Emp. Form. | C31H35N7O3 |
Mol. Mass. | 553.6547 |
SMILES | CCCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN4C(=O)\C=C\COC)n4ccnc(N)c34)c(C)c2)c1 |r| |
Structure |
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