| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM372267 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based Functional Assay of Muscarinic Acetylcholine Receptor Activity |
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| EC50 | 30.0±n/a nM |
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| Citation |  Lindsley, CW; Conn, PJ; Engers, DW; Bollinger, S; Tarr, JC; Spearing, P; Engers, JL; Long, M; Bridges, TM Positive allosteric modulators of the muscarinic acetylcholine receptor M4 US Patent US10239887 Publication Date 3/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52841.70 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
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| Residue: | 477 |
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| Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM372267 |
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| n/a |
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| Name | BDBM372267 |
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| Synonyms: | 3,4-dimethyl-N-(1-(5- (trifluoromethyl) pyrimidin-2-yl)azetidin- 3-yl)pyrimido[4',5':4,5] thieno[2,3-c]pyridazin-8- amine | US10239887, Cpd. No. 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15F3N8S |
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| Mol. Mass. | 432.426 |
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| SMILES | Cc1nnc2sc3c(NC4CN(C4)c4ncc(cn4)C(F)(F)F)ncnc3c2c1C |
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| Structure | 
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