| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [1-324] |
|---|
| Ligand | BDBM202764 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Raf Activity |
|---|
| IC50 | 0.847±n/a nM |
|---|
| Citation |  Aversa, RJ; Barsanti, PA; Burger, MT; Dillon, MP; Dipesa, A; Hu, C; Lou, Y; Nishiguchi, GA; Pan, Y; Polyakov, VR; Ramurthy, S; Rico, AC; Setti, LQ; Smith, A; Subramanian, S; Taft, BR; Tanner, HR; Wan, L; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent US10245267 Publication Date 4/2/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAF proto-oncogene serine/threonine-protein kinase [1-324] |
|---|
| Name: | RAF proto-oncogene serine/threonine-protein kinase [1-324] |
|---|
| Synonyms: | C-Raf TR | P04049 (aa 1-324) | RAF | RAF proto-oncogene serine/threonine-protein kinase (aa 1-324) | RAF1 | RAF1_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 42815.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04049 (aa 1-324) |
|---|
| Residue: | 384 |
|---|
| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTP
|
|
|
|---|
| BDBM202764 |
|---|
| n/a |
|---|
| Name | BDBM202764 |
|---|
| Synonyms: | US10245267, Example 64 | US10709712, Example 64 | US9242969, 111 | US9694016, 64 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22F3N3O2 |
|---|
| Mol. Mass. | 441.4456 |
|---|
| SMILES | Cc1ccc(cc1-c1cc(ccn1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
