Reaction Details | |||
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Target | Gag-Pol polyprotein | ||
Ligand | BDBM372361 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | HIV Cell Culture Assay | ||
EC50 | 19.4±n/a nM | ||
Citation | Sit, S; Chen, Y; Chen, J; Swidorski, J; Venables, BL; Sin, N; Meanwell, NA; Regueiro-Ren, A; Hartz, RA; Xu, L; Liu, Z Triterpenoids with HIV maturation inhibitory activity US Patent US10245275 Publication Date 4/2/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Gag-Pol polyprotein | |||
Name: | Gag-Pol polyprotein | ||
Synonyms: | Capsid protein p24 | Gag-Pol polyprotein (Capsid Protein) | HIV-1 integrase (IN) WT | POL_HV1N5 | Reverse transcriptase (HIV-1 RT) | gag-pol | ||
Type: | Protein | ||
Mol. Mass.: | 161820.05 | ||
Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1) | ||
Description: | P12497 | ||
Residue: | 1435 | ||
Sequence: |
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BDBM372361 | |||
n/a | |||
Name | BDBM372361 | ||
Synonyms: | Preparation of 1-(2-(((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-9-((R)-4-carboxy-4-(fluoromethyl)cyclohex-1-en-1-yl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-3a-yl)amino)ethyl)piperidine-4,4-dicarboxylic acid | US10245275, Example 17 | ||
Type | Small organic molecule | ||
Emp. Form. | C48H73FN2O6 | ||
Mol. Mass. | 793.1014 | ||
SMILES | CCOC(=O)C1(CCN(CCN[C@]23CC[C@H]([C@@H]2[C@H]2CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@](CF)(CC6)C(O)=O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]2(C)CC3)C(C)=C)CC1)C(O)=O |r,t:25,27| | ||
Structure |