| Reaction Details |
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 | Report a problem with these data |
| Target | Homoisocitrate dehydrogenase |
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| Ligand | BDBM23219 |
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| Substrate/Competitor | BDBM23214 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 7.8±n/a |
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| Temperature | 301.15±n/a K |
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| Ki | 3100000±n/a nM |
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| Km | 211000±n/a nM |
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| kcat | 46±n/a 1/sec |
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| Citation |  Yamamoto, T; Miyazaki, K; Eguchi, T Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase. Bioorg Med Chem15:1346-55 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Homoisocitrate dehydrogenase |
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| Name: | Homoisocitrate dehydrogenase |
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| Synonyms: | DraHICDH | Homoisocitrate Dehydrogenase (HICDH) | Isocitrate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35741.95 |
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| Organism: | Deinococcus radiodurans |
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| Description: | Q76G12 |
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| Residue: | 332 |
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| Sequence: | MAKYRICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVPEATYDAV
ENTDATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKTRPVPHSYENVDLVIVR
ENTQGLYVEQERRYGDTAIADTVITREASDRIGKFAADLAMKRSKRLTVVHKSNVLPVTQ
GLFMNTILDHTKTVEGLSTSTMIVDNAAMQLVRNPQQFDVMVMTNMFGDILSDLAAGLVG
GLGIAASGNVGDQFGIFESVHGSAPDIAGQGISNPTATILAAVIMLDHLGDHETARRLDN
AINKVLAEPRTRDLGGTAGTQEFTEAVIKALA
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| BDBM23219 |
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| BDBM23214 |
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| Name | BDBM23219 |
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| Synonyms: | (1R,2E)-1-hydroxypent-2-ene-1,2,5-tricarboxylic acid | 3-Carboxypropylidenemalate, 28a |
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| Type | Small organic molecule |
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| Emp. Form. | C8H10O7 |
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| Mol. Mass. | 218.1608 |
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| SMILES | [H][C@](O)(C(O)=O)C(=C/CCC(O)=O)\C(O)=O |r| |
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| Structure | 
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