| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM375554 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Kinase Assay |
|---|
| IC50 | <100.0±n/a nM |
|---|
| Citation |  Nacro, K; Duraiswamy, AJ; Chennamaneni, LR Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof US Patent US9908886 Publication Date 3/6/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51870.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBH9 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
|
|
|
|---|
| BDBM375554 |
|---|
| n/a |
|---|
| Name | BDBM375554 |
|---|
| Synonyms: | 4-(6-(4-(4-hydroxy-4-methylpiperidine-1-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile | US9908886, Example 106 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H24N4O2 |
|---|
| Mol. Mass. | 436.5051 |
|---|
| SMILES | CC1(O)CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
