| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A2, major isoenzyme |
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| Ligand | BDBM23752 |
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| Substrate/Competitor | BDBM23751 |
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| Meas. Tech. | Fluorimetric Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | >100000±n/a nM |
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| Citation |  Boukli, L; Touaibia, M; Meddad-Belhabich, N; Djimdé, A; Park, CH; Kim, JJ; Yoon, JH; Lamouri, A; Heymans, F Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines. Bioorg Med Chem16:1242-53 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Phospholipase A2, major isoenzyme |
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| Name: | Phospholipase A2, major isoenzyme |
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| Synonyms: | Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 |
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| Type: | Hydrolase; monomer or homodimer |
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| Mol. Mass.: | 16279.83 |
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| Organism: | Sus scrofa (pig) |
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| Description: | Purchased from Sigma. |
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| Residue: | 146 |
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| Sequence: | MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPV
DELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNC
DRNAAICFSKAPYNKEHKNLDTKKYC
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| BDBM23752 |
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| BDBM23751 |
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| Name | BDBM23752 |
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| Synonyms: | 3-{4-[(4-hexadecylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2,4-oxadiazol-5-one | PMS 1062 piperazine deriv., 23b |
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| Type | Small organic molecule |
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| Emp. Form. | C29H48N4O2 |
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| Mol. Mass. | 484.717 |
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| SMILES | CCCCCCCCCCCCCCCCN1CCN(Cc2ccc(cc2)-c2nc(=O)o[nH]2)CC1 |
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| Structure | 
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