| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SMYD3 |
|---|
| Ligand | BDBM378465 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | SMYD3 Biochemical Assay |
|---|
| IC50 | 4.12±n/a nM |
|---|
| Citation |  Foley, MA; Kuntz, KW; Mills, JE; Mitchell, LH; Munchhof, MJ; Harvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent US10266526 Publication Date 4/23/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone-lysine N-methyltransferase SMYD3 |
|---|
| Name: | Histone-lysine N-methyltransferase SMYD3 |
|---|
| Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49101.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H7B4-2 |
|---|
| Residue: | 428 |
|---|
| Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
|
|
|
|---|
| BDBM378465 |
|---|
| n/a |
|---|
| Name | BDBM378465 |
|---|
| Synonyms: | 6-chloro-2-oxo-N-((1R,3S,5S)-8-((((S)-piperidin-3-yl)methyl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)indoline-5-carboxamide | US10266526, Compound 598 | US10266526, Compound 600 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H29ClN4O4S |
|---|
| Mol. Mass. | 481.008 |
|---|
| SMILES | Clc1cc2NC(=O)Cc2cc1C(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2S(=O)(=O)CC1CCCNC1 |r,TLB:22:21:15.14.20:18.17| |
|---|
| Structure | 
|
|---|
Search and Browse
